Pharmacogenetics of GPCRs
We investigate the impact of genetic variations in G protein-coupled receptor (GPCR) structure and signaling pathways on individual patient responses to medications. By identifying specific genetic changes that influence GPCR functionality, we seek to understand the molecular mechanisms underlying variable drug efficacy and adverse effects among patients. Utilizing advanced genomic and proteomic techniques to map these genetic alterations and their effects on receptor signaling will help us to enhance personalized medicine and tailor treatments based on patients’ genetic profiles.
Structure of active µ- and inactive δ-opioid receptor. Nature. 2015 Aug 20; 524(7565): 315–321
GPCRs during Cardiovascular Development
G protein-coupled receptors (GPCRs) serve as important targets of medications administered during pregnancy. We seek to understand how these medications influence cardiovascular development in unborn children. While population-based studies identify side-effects of peripartum medications, we aim to identify the molecular mechanisms through which these drugs affect fetal cardiovascular development. We will utilize novel high-throughput methods to identify genetic susceptibility towards peripartum administered drugs to enhance the safety of maternal-fetal pharmacotherapy and improve health outcomes for unborn children.
Endothelial cell network of 2D organoids
Environmental Effects on GPCR function
The rapidly changing environment is poses risks to human cardiovascular health. Our research aims to develop methods to detect how these environmental changes impact the cardiovascular system. By utilizing human induced pluripotent stem cells (iPSCs) and transgenic mouse models, we will investigate the effects of environmental factors on the heart and vasculature. This approach will allow us to identify molecular and cellular mechanisms underlying cardiovascular responses to environmental stressors, ultimately contributing to the development of strategies for mitigating adverse health effects and improving cardiovascular health in the face of environmental change.
Mouse heart 4 weeks after permanent coronary ligation